ARG54125
anti-CD262 / TRAIL R2 antibody
anti-CD262 / TRAIL R2 antibody for ICC/IF,Western blot and Human,Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody recognizes CD262 / TRAIL R2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | CD262 / TRAIL R2 |
| 抗原物种 | Human |
| 抗原 | Purified recombinant human DR5 protein fragments expressed in E.coli. |
| 偶联标记 | Un-conjugated |
| 別名 | TRICK2A; TRICK2B; KILLER; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; DR5; CD antigen CD262; TRICK2; CD262; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TRAIL-R2; TRAIL receptor 2; TRICKB; ZTNFR9 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 48 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide, 0.1mg/ml BSA and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.1mg/ml BSA, 50% Glycerol |
| 浓度 | 0.4 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14763 Human Tumor necrosis factor receptor superfamily member 10B Swiss-port # Q9QZM4 Mouse Tumor necrosis factor receptor superfamily member 10B |
|---|---|
| 基因名称 | TNFRSF10B |
| 全名 | tumor necrosis factor receptor superfamily, member 10b |
| 背景介绍 | Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis. |
| 生物功能 | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody |
| 预测分子量 | 48 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG54125 anti-CD262 / TRAIL R2 antibody ICC/IF image
Immunofluorescence: HeLa cells fixed by Paraformaldehyde and stained with ARG54125 anti-CD262 / TRAIL R2 antibody at 1:100 dilution.
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ARG54125 anti-CD262 / TRAIL R2 antibody WB image
Western blot: HeLa cell lysate stained with ARG54125 anti-CD262 / TRAIL R2 antibody at 1:500 - 1:2000 dilution.
