ARG54386
anti-CD263 / TRAIL R3 antibody
anti-CD263 / TRAIL R3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD263 / TRAIL R3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 特异性 | This antibody recognizes human, mouse, and rat DcR1 (65kDa). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD263 / TRAIL R3 |
| 抗原物种 | Human |
| 抗原 | Peptide corresponding to aa 111-123 at the extracellular domain (ED) of human DcR1 precursor (accession no. AAB67104). |
| 偶联标记 | Un-conjugated |
| 別名 | Lymphocyte inhibitor of TRAIL; Antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligand receptor 3; DCR1; TRID; CD antigen CD263; Tumor necrosis factor receptor superfamily member 10C; CD263; Decoy TRAIL receptor without death domain; LIT; Decoy receptor 1; DcR1; DCR1-TNFR; TRAIL-R3; TRAIL receptor 3; TRAILR3; TRAIL receptor without an intracellular domain |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa, Mouse liver and Rat liver |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | DEAE purified. |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14798 Human Tumor necrosis factor receptor superfamily member 10C |
|---|---|
| 基因名称 | TNFRSF10C |
| 全名 | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
| 背景介绍 | TRAIL/Apo2L is a new member of the TNF family that induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has an extracellular TRAIL-binding domain but lacks an intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expessed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 does not induce apoptosis but attenuates TRAIL-induced apoptosis. |
| 生物功能 | Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | N-glycosylated and O-glycosylated. |
检测图片 (2) Click the Picture to Zoom In
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ARG54386 anti-CD263 / TRAIL R3 antibody WB image
Western blot: A:HeLa ; B: Mouse liver; C:rat liver tissue stained with ARG54386 anti-CD263 / TRAIL R3 antibody at 1 μg/ml dilution.
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ARG54386 anti-CD263 / TRAIL R3 antibody ICC/IF image
Immunofluorescence: Rat liver stained with ARG54386 anti-CD263 / TRAIL R3 antibody at 10 μg/ml dilution.
