ARG53808
anti-CD263 / TRAIL R3 antibody [TRAIL-R3-02] (FITC)
anti-CD263 / TRAIL R3 antibody [TRAIL-R3-02] (FITC) for Flow cytometry and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [TRAIL-R3-02] recognizes CD263 / TRAIL R3 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | TRAIL-R3-02 |
| 同位型 | IgG1 |
| 靶点名称 | CD263 / TRAIL R3 |
| 抗原 | TRAIL-R3 (aa 1-280) - hIgGhc fusion protein |
| 偶联标记 | FITC |
| 別名 | Lymphocyte inhibitor of TRAIL; Antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligand receptor 3; DCR1; TRID; CD antigen CD263; Tumor necrosis factor receptor superfamily member 10C; CD263; Decoy TRAIL receptor without death domain; LIT; Decoy receptor 1; DcR1; DCR1-TNFR; TRAIL-R3; TRAIL receptor 3; TRAILR3; TRAIL receptor without an intracellular domain |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14798 Human Tumor necrosis factor receptor superfamily member 10C |
|---|---|
| 基因名称 | TNFRSF10C |
| 全名 | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
| 背景介绍 | TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5). |
| 生物功能 | Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | N-glycosylated and O-glycosylated. |
