ARG54410
anti-CD264 / TRAIL R4 antibody
anti-CD264 / TRAIL R4 antibody for ICC/IF,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD264 / TRAIL R4 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 特异性 | This antibody recognizes full-length DcR2 (34kDa). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD264 / TRAIL R4 |
| 抗原物种 | Human |
| 抗原 | Peptide corresponding to aa 249-263 of human DcR2 precursor (accession no. Q9UBN6). |
| 偶联标记 | Un-conjugated |
| 別名 | Tumor necrosis factor receptor superfamily member 10D; CD264; DCR2; CD antigen CD264; DcR2; Decoy receptor 2; TNF-related apoptosis-inducing ligand receptor 4; TRUNDD; TRAILR4; TRAIL receptor with a truncated death domain; TRAIL receptor 4; TRAIL-R4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UBN6 Human Tumor necrosis factor receptor superfamily member 10D |
|---|---|
| 基因名称 | TNFRSF10D |
| 全名 | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| 背景介绍 | TRAIL/Apo2L is a new member of the TNF family and induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a "decoy receptor". Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks an intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuates TRAIL-induced apoptosis. |
| 生物功能 | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 42 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG54410 anti-CD264 / TRAIL R4 antibody WB image
Western blot: HeLa stained with ARG54410 anti-CD264 / TRAIL R4 antibody at 1 μg/ml dilution.
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ARG54410 anti-CD264 / TRAIL R4 antibody ICC/IF image
Immunofluorescence: HeLa stained with ARG54410 anti-CD264 / TRAIL R4 antibody at 10 μg/ml dilution.
