ARG62792
anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01]
anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] for Flow cytometry and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
概述
| 产品描述 | Mouse Monoclonal antibody [TRAIL-R4-01] recognizes CD264 / TRAIL R4 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | TRAIL-R4-01 |
| 同位型 | IgG1 |
| 靶点名称 | CD264 / TRAIL R4 |
| 抗原 | TRAIL-R4 (aa 1-210) - hIgGhc fusion protein |
| 偶联标记 | Un-conjugated |
| 別名 | Tumor necrosis factor receptor superfamily member 10D; CD264; DCR2; CD antigen CD264; DcR2; Decoy receptor 2; TNF-related apoptosis-inducing ligand receptor 4; TRUNDD; TRAILR4; TRAIL receptor with a truncated death domain; TRAIL receptor 4; TRAIL-R4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 纯化说明 | 0.2 µm filter sterilized. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UBN6 Human Tumor necrosis factor receptor superfamily member 10D |
|---|---|
| 基因名称 | TNFRSF10D |
| 全名 | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| 背景介绍 | TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4). |
| 生物功能 | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 42 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG62792 anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] FACS image
Flow Cytometry: Separation of CD264 transfected HEK-293 cells (red-filled) from non-transfected HEK-293 cells (black-dashed). Human peripheral whole blood stained with ARG62792 anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] at 0.33 µg/ml dilution, followed by APC-conjugated Goat anti-Mouse antibody.
