ARG53810
anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (FITC)
anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (FITC) for Flow cytometry and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [TRAIL-R4-01] recognizes CD264 / TRAIL R4 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | TRAIL-R4-01 |
| 同位型 | IgG1 |
| 靶点名称 | CD264 / TRAIL R4 |
| 抗原 | TRAIL-R4 (aa 1-210) - hIgGhc fusion protein |
| 偶联标记 | FITC |
| 別名 | Tumor necrosis factor receptor superfamily member 10D; CD264; DCR2; CD antigen CD264; DcR2; Decoy receptor 2; TNF-related apoptosis-inducing ligand receptor 4; TRUNDD; TRAILR4; TRAIL receptor with a truncated death domain; TRAIL receptor 4; TRAIL-R4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UBN6 Human Tumor necrosis factor receptor superfamily member 10D |
|---|---|
| 基因名称 | TNFRSF10D |
| 全名 | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| 背景介绍 | TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4). |
| 生物功能 | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 42 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG53810 anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (FITC) FACS image
Flow Cytometry: CD264 transfected HEK-293 cells stained with ARG53810 anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (FITC) at 1 µg/ml dilution.
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ARG53810 anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (FITC) FACS image
Flow Cytometry: Separation of CD264 transfected HEK-293 cells stained with ARG53810 anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (FITC) at 1 µg/ml dilution (red-filled) from CD264 transfected HEK-293 cells stained with ARG65328 Mouse IgG1 Kappa Isotype Control antibody [MOPC-21] (FITC) at 1 µg/ml dilution (black-dashed).
