ARG42458
anti-CD268 / BAFF R antibody [11C1]
anti-CD268 / BAFF R antibody [11C1] for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [11C1] recognizes CD268 / BAFF R |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-Fr, IHC-P |
| 特异性 | The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor), a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 11C1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD268 / BAFF R |
| 抗原物种 | Human |
| 抗原 | Human CD268-transfected murine L1.2 cells. |
| 偶联标记 | Un-conjugated |
| 別名 | CD antigen CD268; BROMIX; BAFF-R; CD268; Tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BAFFR; B-cell-activating factor receptor; prolixin; CVID4; BLyS receptor 3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
GeneID: 115650 Human TNFRSF13C Swiss-port # Q96RJ3 Human Tumor necrosis factor receptor superfamily member 13C |
|---|---|
| 基因名称 | TNFRSF13C |
| 全名 | tumor necrosis factor receptor superfamily, member 13C |
| 背景介绍 | B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008] |
| 生物功能 | B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. [UniProt] |
| 细胞定位 | Membrane; Single-pass type III membrane protein. [UniProt] |
| 预测分子量 | 19 kDa |
