ARG54286
anti-CD271 / NGFR p75 antibody [NGFR5] (APC)
anti-CD271 / NGFR p75 antibody [NGFR5] (APC) for Flow cytometry and Human,Cat,Ferret,Primates,Rabbit
Developmental Biology antibody; Neuroscience antibody
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [NGFR5] recognizes CD271 / NGFR p75 |
|---|---|
| 反应物种 | Hu, Cat, Frt, NHuPrm, Rb |
| 不反应物种 | Ms, Rat |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody NGFR5 (originally C34C) recognizes CD271 / NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within amino acids 1 - 160. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | NGFR5 |
| 同位型 | IgG1 |
| 靶点名称 | CD271 / NGFR p75 |
| 抗原物种 | Human |
| 抗原 | Purified CD271 protein isolated from human melanoma cell line A875 |
| 偶联标记 | APC |
| 別名 | Gp80-LNGFR; CD271; CD antigen CD271; p75 ICD; Tumor necrosis factor receptor superfamily member 16; p75NTR; NGF receptor; TNFRSF16; p75(NTR); Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P08138 Human Tumor necrosis factor receptor superfamily member 16 |
|---|---|
| 基因名称 | NGFR |
| 全名 | nerve growth factor receptor |
| 背景介绍 | CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells. |
| 生物功能 | Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. [UniProt] |
| 研究领域 | Developmental Biology antibody; Neuroscience antibody |
| 预测分子量 | 45 kDa |
| 翻译后修饰 | N- and O-glycosylated. O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. Phosphorylated on serine residues. |
检测图片 (1) Click the Picture to Zoom In
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ARG54286 anti-CD271 / NGFR p75 antibody [NGFR5] (APC) FACS image
Flow Cytometry: REH cells stained with ARG54286 anti-CD271 / NGFR p75 antibody [NGFR5] (APC).
克隆号文献
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Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency mice.
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Modulation of Fas-induced apoptosis by p75 neurotrophin receptor in a human neuroblastoma cell line.
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