ARG65401
anti-CD328 / Siglec 7 antibody [6-434]
anti-CD328 / Siglec 7 antibody [6-434] for CyTOF®-candidate,Flow cytometry and Human
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody
概述
| 产品描述 | Mouse Monoclonal antibody [6-434] recognizes CD328 / Siglec 7 |
|---|---|
| 反应物种 | Hu |
| 应用 | CyTOF®-candidate, FACS |
| 特异性 | The mouse monoclonal antibody 6434 recognizes CD328 (Siglec7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes. HLDA 8; WS Code ARN80652 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 6-434 |
| 同位型 | IgG1 |
| 靶点名称 | CD328 / Siglec 7 |
| 抗原物种 | Human |
| 抗原 | human dendritic cells |
| 偶联标记 | Un-conjugated |
| 別名 | QA79 membrane protein; p75; CD antigen CD328; SIGLEC19P; Adhesion inhibitory receptor molecule 1; SIGLECP2; Sialic acid-binding Ig-like lectin 7; SIGLEC-7; p75/AIRM1; CDw328; Siglec-7; AIRM-1; CD328; AIRM1; D-siglec; QA79 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from cell culture supernatant by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y286 Human Sialic acid-binding Ig-like lectin 7 |
|---|---|
| 基因名称 | SIGLEC7 |
| 全名 | sialic acid binding Ig-like lectin 7 |
| 背景介绍 | CD328, also known as Siglec-7 or p75/AIRM1, is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with alpha2,6 sialyl and alpha2,8 disyalyl residues and mediates sialic acid-dependent cell-cell binding. As it contains in its intracellular part the immunoreceptor tyrosine-based inhibitory motif (ITIM), it serves as an inhibitory receptor, e.g. of NK cells. |
| 生物功能 | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). [UniProt] |
| 产品亮点 | Related products: CD328 antibodies; CD328 ELISA Kits; Anti-Mouse IgG secondary antibodies; Related news: CyTOF-candidate Antibodies |
| 研究领域 | Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | Tyrosine phosphorylated. |
