ARG23573
anti-CD32B antibody [AT130-5R]
anti-CD32B antibody [AT130-5R] for IHC-Frozen sections and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [AT130-5R] recognizes CD32B. Rat anti Mouse CD32B, clone AT130-5R, recognizes mouse CD32B also known as FcRIIB. CD32B (FcRIIB) is a low affinity receptor for IgG1, IgG2a and IgG2b type antibodies. Unlike other FcRs, the intracellular domain of CD32 contains a inhibitory signalling motif (ITIM) that can antagonize signal transduction mediated through other activatory receptors. FcRIIB is expressed on all myeloid populations and on B-cells. |
|---|---|
| 反应物种 | Ms |
| 应用 | IHC-Fr |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | AT130-5R |
| 同位型 | IgG2b |
| 靶点名称 | CD32B |
| 抗原物种 | Mouse |
| 抗原 | Mouse CD32-Rat CD4 fusion protein. |
| 偶联标记 | Un-conjugated |
| 別名 | Fc-gamma-RIIc; Fc-gamma RII-c; CD32; CD antigen CD32; CD32B; IgG Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II-c; FCG2; IGFR2; FcRII-c; FCGR2; CDw32 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | TRIS buffered saline and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P08101 Mouse Low affinity immunoglobulin gamma Fc region receptor II |
|---|---|
| 基因名称 | FCGR2B |
| 全名 | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
| 背景介绍 | The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| 生物功能 | Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. [UniProt] |
| 预测分子量 | 36 kDa |
| 翻译后修饰 | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG23573 anti-CD32B antibody [AT130-5R] IHC-Fr image
Immunohistochemistry: Acetone-fixed frozen sections of BALB/c WT and CD32B -/- Mouse spleen and liver (10 µm) stained with ARG23573 anti-CD32B antibody [AT130-5R] at 5 µg/ml followed by an anti-Rat IgG HRP polymer and counterstained with Haematoxylin.
