ARG43670
anti-CD35 / CR1 antibody [CR1/802]
anti-CD35 / CR1 antibody [CR1/802] for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [CR1/802] recognizes CD35 / CR1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CR1/802 |
| 同位型 | IgG |
| 靶点名称 | CD35 / CR1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to Human CD35 / CR1. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Complement receptor type 1 |
| 別名 | C3b/C4b receptor; C4BR; CD antigen CD35; KN; CD35; C3BR; Complement receptor type 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen retrieval: Boil formalin-fixed, paraffin-embedded tissue sections in 10mM Citrate buffer (pH 6.0) for 10-20 min followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CR1 |
| 全名 | complement component (3b/4b) receptor 1 (Knops blood group) |
| 背景介绍 | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a Monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008] |
| 生物功能 | Mediates cellular binding of particles and immune complexes that have activated complement. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 224 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid |
检测图片 (1) Click the Picture to Zoom In
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ARG43670 anti-CD35 / CR1 antibody [CR1/802] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Mouse Kidney tissue stained with ARG43670 anti-CD35 / CR1 antibody [CR1/802] at 1:200 dilution. Antigen Retrieval: Heat mediated was performed using 10 mM citrate buffer pH 6.0
