ARG57570
anti-CD41-CD61 Complex antibody [PAC-1] (FITC)
anti-CD41-CD61 Complex antibody [PAC-1] (FITC) for Flow cytometry,ICC/IF and Human
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [PAC-1] recognizes CD41-CD61 Complex |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF |
| 特异性 | The antibody recognizes an activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | PAC-1 |
| 同位型 | IgM |
| 靶点名称 | CD41-CD61 Complex |
| 抗原物种 | Human |
| 抗原 | Human platelets. |
| 偶联标记 | FITC |
| 別名 | GTA; GT; GPalpha IIb; PPP1R93; CD41; BDPLT2; BDPLT16; GP2B; Integrin alpha-IIb; GPIIb; Platelet membrane glycoprotein IIb; HPA3; CD antigen CD41; CD41B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified. |
| 缓冲液 | Tris buffered saline and 15mM Sodium azide. |
| 抗菌剂 | 15mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGA2B |
| 全名 | ITGA2B |
| 背景介绍 | ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] |
| 生物功能 | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProt] |
| 预测分子量 | 113 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG57570 anti-CD41-CD61 Complex antibody [PAC-1] (FITC) FACS image
Flow Cytometry: PHA-activated (1 hour) Human peripheral blood stained with ARG57570 anti-CD41-CD61 Complex antibody [PAC-1] (FITC) (right histogram) or without primary antibody as control (left histogram).
