ARG22148
anti-CD44 antibody [F10-44-2] (PE)
anti-CD44 antibody [F10-44-2] (PE) for Blocking,Cellular activation ,Depletion,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Purification,Western blot and Human
Cancer antibody; Developmental Biology antibody; Immune System antibody; Chondrogenesis Study antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [F10-44-2] recognizes CD44 |
|---|---|
| 反应物种 | Hu |
| 应用 | BL, Cell-Act , Depletion, FACS, ICC/IF, IHC-Fr, IHC-P, Puri, WB |
| 特异性 | Human CD44 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | F10-44-2 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | CD44 |
| 抗原物种 | Human |
| 抗原 | Purified Human T cells |
| 偶联标记 | PE |
| 別名 | MDU2; MDU3; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; Extracellular matrix receptor III; PGP-I; Epican; CDW44; Phagocytic glycoprotein 1; Pgp1; HUTCH-I; MC56; Hyaluronate receptor; CD antigen CD44; Heparan sulfate proteoglycan; CD44 antigen; LHR; IN; HCELL; Phagocytic glycoprotein I; PGP-1; CSPG8; MIC4; ECMR-III; CDw44 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS, 0.1% Sodium azide and Sucrose. |
| 抗菌剂 | 0.1% Sodium azide |
| 稳定剂 | Sucrose |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD44 |
| 全名 | CD44 molecule (Indian blood group) |
| 背景介绍 | The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. [UniProt] |
| 研究领域 | Cancer antibody; Developmental Biology antibody; Immune System antibody; Chondrogenesis Study antibody |
| 预测分子量 | 82 kDa |
| 翻译后修饰 | Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638. Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672. |
检测图片 (1) Click the Picture to Zoom In
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ARG22148 anti-CD44 antibody [F10-44-2] (PE) FACS image
Flow Cytometry: Human peripheral blood lymphocytes stained with ARG22148 anti-CD44 antibody [F10-44-2] (PE).
