ARG57601
anti-CD49b / Integrin alpha 2 antibody
anti-CD49b / Integrin alpha 2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD49b / Integrin alpha 2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD49b / Integrin alpha 2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Integrin alpha 2. |
| 偶联标记 | Un-conjugated |
| 別名 | Collagen receptor; VLA-2 subunit alpha; HPA-5; CD49B; CD49 antigen-like family member B; GPIa; VLA-2; CD antigen CD49b; BR; VLAA2; Platelet membrane glycoprotein Ia; Integrin alpha-2 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Microwave (8 min, twice) tissue section in Sodium citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGA2 |
| 全名 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
| 背景介绍 | This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| 生物功能 | Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. [UniProt] |
| 细胞定位 | Cytoplasm |
| 预测分子量 | 129 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG57601 anti-CD49b / Integrin alpha 2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse kidney tissue. Antigen Retrieval: Tissue section in Sodium citrate buffer (pH 6.0) heated in 900W for 8 min and heated again for 8 min at 750W. The tissue section was stained with ARG57601 anti-CD49b / Integrin alpha 2 antibody at 1:50 dilution, overnight at 4°C.
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ARG57601 anti-CD49b / Integrin alpha 2 antibody WB image
Western blot: A431 cell lysate stained with ARG57601 anti-CD49b / Integrin alpha 2 antibody.
