ARG44613
anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE)
anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE) for Flow cytometry and Human,Primates
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody recognizes CD49e / Integrin alpha 5 |
|---|---|
| 反应物种 | Hu, NHuPrm |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SAM1 |
| 同位型 | IgG2b |
| 靶点名称 | CD49e / Integrin alpha 5 |
| 抗原物种 | Human |
| 抗原 | U937 cells |
| 偶联标记 | PE |
| 別名 | ITGA5; Integrin Subunit Alpha 5; CD49e; FNRA; Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide); Fibronectin Receptor, Alpha Polypeptide; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-5; Integrin Alpha-F; VLA-5; Very Late Activation Protein 5, Alpha Subunit ; Fibronectin Receptor, Alpha Subunit; ITGA5/SLC9B1 Fusion; CD49e Antigen; VLA5A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified antibody is conjugated with R-phycoerythrin (PE), and free fluorochrome are removed by size-exclusion chromatography. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGA5 |
| 全名 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
| 背景介绍 | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] |
| 生物功能 | Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt] |
| 细胞定位 | Cell junction, Cell membrane, Membrane. [UniProt] |
| 预测分子量 | 115 kDa |
| 翻译后修饰 | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG44613 anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG44613 anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE) at 10 μl/ 100 μl dilution.
