ARG67227
anti-CD63 antibody
anti-CD63 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD63 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD63 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (extracellular domain) form Human CD63. |
| 偶联标记 | Un-conjugated |
| 別名 | CD63; CD63 Molecule; TSPAN30; ME491; MLA1; Ocular Melanoma-Associated Antigen; CD63 Antigen (Melanoma 1 Antigen); Melanoma-Associated Antigen ME491; Tetraspanin-30; Granulophysin; CD63 Antigen; Tspan-30; OMA81H; Limp1; Lysosomal-Associated Membrane Protein 3; Lysosome Integral Membrane Protein 1; Melanoma-Associated Antigen MLA1; LAMP-3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 20-50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 100 mM Tris Glycine (pH 7.0), 0.025% ProClin 300 and 20% Glycerol. |
| 抗菌剂 | 0.025% ProClin 300 |
| 稳定剂 | 20% Glycerol |
| 浓度 | 1.51 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD63 |
| 全名 | CD63 Molecule |
| 背景介绍 | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012] |
| 生物功能 | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. [Uniprot] |
| 细胞定位 | Cell membrane, Endosome, Lysosome, Membrane, Secreted. [Uniprot] |
| 预测分子量 | 26 kDa |
| 翻译后修饰 | Glycoprotein, Lipoprotein, Palmitate. [Uniprot] |
检测图片 (3) Click the Picture to Zoom In
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ARG67227 anti-CD63 antibody IHC-P image
Immunohistochemistry: hepatocellular carcinoma stained with ARG67227 anti-CD63 antibody at 1:100 dilution.
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ARG67227 anti-CD63 antibody WB image
Western blot: THP-1, U87MG stained with ARG67227 anti-CD63 antibody at 1:1000 dilution.
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ARG67227 anti-CD63 antibody WB image
Western blot: PC-3 stained with ARG67227 anti-CD63 antibody at 1:1000 dilution.
