ARG43649

anti-CD68 antibody

Datasheet

参考文献1

订购信息

包装

价格 (USD)

100 μl

399

arigo in CHINA:
恩瑞科生物
☎ 400-886-0853,
0571-8708-1890

概述

产品描述	Rabbit Polyclonal antibody recognizes CD68
反应物种	Hu, Ms, Rat
应用	ICC/IF, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	CD68
抗原物种	Human
抗原	Recombinant protein fragment within a.a. 150-350 of Human CD68.
偶联标记	Un-conjugated
Protein Full name	Macrosialin
別名	Macrosialin; CD antigen CD68; LAMP4; Gp110; GP110; SCARD1

应用说明

应用建议

应用	推荐稀释比
ICC/IF	1:50 - 1:200
WB	1:500 - 1:2000

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

实际分子量

80-130 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
浓度	Batch dependent
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 12514 Mouse CD68 GeneID: 968 Human CD68 Swiss-port # P31996 Mouse Macrosialin Swiss-port # P34810 Human Macrosialin
基因名称	CD68
全名	CD68 molecule
背景介绍	CD68 is a 110-kD transmembrane glycoprotein that is highly expressed by human Polycytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
生物功能	CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. [UniProt]
细胞定位	Cell membrane; Endosome; Lysosome; Membrane
产品亮点	Related Antibody Duos and Panels: ARG30325 Inflammatory Cell Antibody Panel Related products: CD68 antibodies; CD68 Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: Cancer Pathology Markers (SQ clones) New antibody panels and duos for Tumor immune microenvironment Tumor-Infiltrating Lymphocytes (TILs) Exploring Antiviral Immune Response Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH
研究领域	Immune System antibody; Activated Macrophage/Microglia Study antibody; Neuroinflammation Study antibody; Active macroglial Marker antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M1 macrophage Marker antibody; Inflammatory Cell Marker antibody
预测分子量	37 kDa
翻译后修饰	N- and O-glycosylated. [UniProt]

检测图片 (3) Click the Picture to Zoom In

ARG43649 anti-CD68 antibody ICC/IF image

Immunofluorescence: THP-1 cells stained with ARG43649 anti-CD68 antibody at 1:250 dilution.
ARG43649 anti-CD68 antibody WB image

Western blot: Mouse liver and Rat liver stained with ARG43649 anti-CD68 antibody at 1:10000 dilution, overnight at 4°C.
ARG43649 anti-CD68 antibody WB image

Western blot: RAW264.7 cell lysates stained with ARG43649 anti-CD68 antibody at 1:10000 dilution, overnight at 4°C.