ARG20946
anti-CD71 / Transferrin Receptor antibody [RI7217] (low endotoxin)
anti-CD71 / Transferrin Receptor antibody [RI7217] (low endotoxin) for Blocking,Flow cytometry,ICC/IF,Immunoprecipitation,Western blot and Mouse
概述
| 产品描述 | Azide free and low endotoxin Rat Monoclonal antibody [RI7217] recognizes CD71 / Transferrin Receptor |
|---|---|
| 反应物种 | Ms |
| 应用 | BL, FACS, ICC/IF, IP, WB |
| 特异性 | Mouse CD71. The clone RI7217 inhibits cell proliferation in vitro. |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | RI7217 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | CD71 / Transferrin Receptor |
| 抗原物种 | Mouse |
| 抗原 | DMSO induced Friend erythroleukemia 745.6 |
| 偶联标记 | Un-conjugated |
| 別名 | TFR1; CD antigen CD71; CD71; T9; p90; TR; Trfr; Transferrin receptor protein 1; TRFR; sTfR; TfR1; TfR; TFR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | Low endotoxin |
| 缓冲液 | PBS |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TFRC |
| 全名 | transferrin receptor |
| 背景介绍 | This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] |
| 生物功能 | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. [UniProt] |
| 预测分子量 | 85 kDa |
| 翻译后修饰 | N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. |
