ARG52811

anti-CD79a antibody

Datasheet

订购信息

包装

价格 (USD)

500 μl

379

arigo in CHINA:
恩瑞科生物
☎ 400-886-0853,
0571-8708-1890

产品说明书

概述

产品描述	Rabbit Polyclonal antibody recognizes CD79a
反应物种	Hu
预测物种	Dog
应用	IHC-P
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	CD79a
抗原物种	Human
抗原	Synthetic peptide derived from N-terminus of human CD79a protein.
偶联标记	Un-conjugated
別名	Surface IgM-associated protein; B-cell antigen receptor complex-associated protein alpha chain; Membrane-bound immunoglobulin-associated protein; Ig-alpha; MB-1 membrane glycoprotein; MB-1; IGA; CD antigen CD79a

应用说明

应用建议

应用	推荐稀释比
IHC-P	1:200

应用说明

IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Incubation Time: 10 min at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

B Cell Lymphoma, Tonsil, Raji

属性

形式	Liquid
纯化	Immunogen affinity purified
缓冲液	PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide
抗菌剂	< 0.1% Sodium azide
稳定剂	1% BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 973 Human CD79A Swiss-port # P11912 Human B-cell antigen receptor complex-associated protein alpha chain
背景介绍	CD79a: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
生物功能	CD79a is required in cooperation with CD79b for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. [UniProt]
细胞定位	Membrane
产品亮点	Related products: CD79a antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Lymphoma Tumor-Infiltrating Lymphocytes (TILs)
研究领域	Cancer antibody; Developmental Biology antibody; Immune System antibody
预测分子量	25 kDa
翻译后修饰	Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation. Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).