ARG42413
anti-CD85g / ILT7 antibody [17G10.2] (PE)
anti-CD85g / ILT7 antibody [17G10.2] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [17G10.2] recognizes CD85g / ILT7 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 17G10.2 recognizes an extracellular epitope of CD85g / ILT7, a member of leukocyte immunoglobulin-like receptor family expressed on plasmacytoid dendritic cells, but not on myeloid dendritic cells and other peripheral blood leukocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 17G10.2 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD85g / ILT7 |
| 抗原物种 | Human |
| 抗原 | Human CD85g / ILT7. |
| 偶联标记 | PE |
| 別名 | ILT7; ILT-7; CD85 antigen-like family member G; Immunoglobulin-like transcript 7; CD antigen CD85g; CD85g; Leukocyte immunoglobulin-like receptor subfamily A member 4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P59901 Human Leukocyte immunoglobulin-like receptor subfamily A member 4 |
|---|---|
| 基因名称 | LILRA4 |
| 全名 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 |
| 背景介绍 | This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015] |
| 生物功能 | Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 55 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42413 anti-CD85g / ILT7 antibody [17G10.2] (PE) FACS image
Flow Cytometry: Human peripheral blood stained with ARG42413 anti-CD85g / ILT7 antibody [17G10.2] (PE) and co-stained with anti-HLA DR antibody (APC).
