ARG62936
anti-CD86 antibody [GL-1] (FITC)
anti-CD86 antibody [GL-1] (FITC) for Blocking,Flow cytometry,IHC-Frozen sections and Mouse
Developmental Biology antibody; Immune System antibody; Microbiology and Infectious Disease antibody
概述
| 产品描述 | FITC-conjugated Rat Monoclonal antibody [GL-1] recognizes CD86 |
|---|---|
| 反应物种 | Ms |
| 应用 | BL, FACS, IHC-Fr |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | GL-1 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | CD86 |
| 抗原物种 | Mouse |
| 抗原 | LPS-activated CBA/Ca mouse spleen B cells |
| 偶联标记 | FITC |
| 別名 | B70; B7.2; LAB72; CD antigen CD86; B7-2; FUN-1; CD28LG2; T-lymphocyte activation antigen CD86; CTLA-4 counter-receptor B7.2; Activation B7-2 antigen; BU63 |
应用说明
| 应用建议 |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS and 0.1% Sodium azide. |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 0.5 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P42082 Mouse T-lymphocyte activation antigen CD86 |
|---|---|
| 基因名称 | Cd86 |
| 全名 | CD86 antigen |
| 背景介绍 | CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response. |
| 生物功能 | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. [UniProt] |
| 研究领域 | Developmental Biology antibody; Immune System antibody; Microbiology and Infectious Disease antibody |
| 预测分子量 | 38 kDa |
| 翻译后修饰 | Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
检测图片 (1) Click the Picture to Zoom In
-
ARG62936 anti-CD86 antibody [GL-1] (FITC) FACS image
Flow Cytometry: DBA/2 Mouse mastocytoma cell line P815 and mB7.2-Ig transfected P815 cells stained with ARG62936 anti-CD86 antibody [GL-1] (FITC).
克隆号文献
Inflammatory cascades mediate synapse elimination in spinal cord compression.
IHC-FoFr / Mouse
Live single cell functional phenotyping in droplet nano-liter reactors.
Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells.
Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells.
Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness.
