ARG52839
anti-CDX2 antibody [SP54]
anti-CDX2 antibody [SP54] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections and Human
Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody
概述
| 产品描述 | Rabbit Monoclonal antibody [SP54] recognizes CDX2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SP54 |
| 同位型 | IgG |
| 靶点名称 | CDX2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to N-terminus of human CDX2. |
| 偶联标记 | Un-conjugated |
| 別名 | CDX2/AS; CDX3; Homeobox protein CDX-2; CDX-3; Caudal-type homeobox protein 2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Incubation Time: 30 min at RT. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | Colon Carcinoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by protein A/G |
| 缓冲液 | PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide |
| 抗菌剂 | < 0.1% Sodium azide |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | CDX2 is a caudal type homeobox gene that encodes an intenstine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared in CK20. |
| 细胞定位 | Nucleus |
| 产品亮点 | Related products: CDX2 antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Wnt / beta-catenin signaling for gastric fundus specification |
| 研究领域 | Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody |
| 预测分子量 | 34 kDa |
| 翻译后修饰 | Phosphorylation of Ser-60 mediates the transactivation capacity. |
检测图片 (1) Click the Picture to Zoom In
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ARG52839 anti-CDX2 antibody [SP54] IHC-P image
Immunohistochemistry: Human Colon Adenoarcinoma stained with CDX2 antibody [SP54] (ARG52839)
克隆号文献
5-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell line HTR8/SVneo.
ICC/IF / Human
