ARG43641
anti-CLEC2 / CLEC1B antibody
anti-CLEC2 / CLEC1B antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CLEC2 / CLEC1B |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | This antibody can block the interaction of human CLEC-2 with its endogenous ligand Podoplanin. This antibody does not cross react with Rabbit CLEC-2 when tested via FACS. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CLEC2 / CLEC1B |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within a.a. 40-80 of Human CLEC2. |
| 偶联标记 | Un-conjugated |
| Protein Full name | C-type lectin domain family 1 member B |
| 別名 | CLEC2; C-type lectin domain family 1 member B; CLEC2B; PRO1384; C-type lectin-like receptor 2; CLEC-2; 1810061I13Rik; QDED721 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 28 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9P126 Human C-type lectin domain family 1 member B |
|---|---|
| 基因名称 | CLEC1B |
| 全名 | C-type lectin domain family 1, member B |
| 背景介绍 | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
| 生物功能 | C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485). (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507). [UniProt] |
| 细胞定位 | Membrane |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG43641 anti-CLEC2 / CLEC1B antibody WB image
Western blot: Human testis lysates were stained with ARG43641 anti-CLEC2 / CLEC1B antibody at 1:2000 dilution, overnight at 4°C.
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ARG43641 anti-CLEC2 / CLEC1B antibody WB image
Western blot: HepG2 cells lysates were stained with ARG43641 anti-CLEC2 / CLEC1B antibody at 1:2000 dilution, overnight at 4°C.
