ARG41306
anti-CSRP3 antibody
anti-CSRP3 antibody for Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CSRP3 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms, Cow, Dog, Gpig, Hrs, Rb |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CSRP3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the middle region of Human CSRP3. (within the following region: QGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCG) |
| 偶联标记 | Un-conjugated |
| 別名 | CMH12; LIM domain protein, cardiac; Cysteine and glycine-rich protein 3; LMO4; Muscle LIM protein; MLP; CMD1M; CRP3; Cysteine-rich protein 3; Cardiac LIM protein; CLP |
应用说明
| 预测反应性说明 | Predicted Homology Based On Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea pig: 100%; Horse: 100%; Mouse: 100%; Rabbit: 100% | ||||
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| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Human heart |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P50461 Human Cysteine and glycine-rich protein 3 |
|---|---|
| 基因名称 | CSRP3 |
| 全名 | cysteine and glycine-rich protein 3 (cardiac LIM protein) |
| 背景介绍 | This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere. Note=Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity). Isoform 2: Cytoplasm, myofibril, sarcomere, Z line. [UniProt] |
| 预测分子量 | 21 kDa |
| 翻译后修饰 | Phosphorylated by PKC/PRKCA. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41306 anti-CSRP3 antibody WB image
Western blot: Human heart lysate stained with ARG41306 anti-CSRP3 antibody at 0.2-1 µg/ml dilution.
