概述

产品描述	Rabbit Polyclonal antibody recognizes Claudin 1
反应物种	Hu, Ms, Rat
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	Claudin 1
抗原物种	Human
抗原	Synthetic peptide of Human Claudin 1.
偶联标记	Un-conjugated
別名	ILVASC; Senescence-associated epithelial membrane protein; CLD1; SEMP1; Claudin-1

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量	~ 18 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 12737 Mouse CLDN1 GeneID: 65129 Rat CLDN1 GeneID: 9076 Human CLDN1 Swiss-port # O88551 Mouse Claudin-1 Swiss-port # O95832 Human Claudin-1 Swiss-port # P56745 Rat Claudin-1 More
基因名称	CLDN1
全名	claudin 1
背景介绍	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
生物功能	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. CLDN1 acts as a coreceptor for HCV entry into hepatic cells. [UniProt]
细胞定位	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. [UniProt]
预测分子量	23 kDa

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