ARG67014
anti-Claudin 18.2 antibody [SQab22278]
anti-Claudin 18.2 antibody [SQab22278] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab22278] recognizes Claudin 18.2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab22278 |
| 同位型 | IgG |
| 靶点名称 | Claudin 18.2 |
| 抗原物种 | Human |
| 抗原 | Recombinant Protein of Human Claudin 18.2. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Claudin-18.2 |
| 別名 | Isoform 2 of Claudin-18; Claudin-18 isoform 2; Claudin-18.2; Anti-Claudin 18.2 Antibody; SQab22278; Arigo Biolaboratories; Western blot; immunoprecipitation; immunofluorescence; tight junctions; epithelial cells; protein expression; tissue and cell studies; research use |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | Human stomach; Human stomach cancer; Human lung adenocarcinoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CLDN18.2 |
| 全名 | Claudin 18.2 |
| 背景介绍 | Claudin18.2 (CLDN18.2) is a splice variant of the membrane epithelial tight junctions protein Claudin18 (CLDN18) and has been identified as a promising biomarker for targeted therapy. While upon malignant transformation, the changes in cell polarity lead to the exposure of CLDN18.2 epitopes. which are suitable for targeted therapy. Prior evidence demonstrates that except for GC, CLDN18.2 is aberrantly expressed in various primary tumors and metastases, including pancreatic, biliary, ovarian, and lung adenocarcinomas, which makes CLDN18.2 a pan-cancer target. CLDN18.2 has a restricted expression profile in normal tissues, it physiologically expresses only in the tight junction supramolecular complex of gastric mucosa. |
| 生物功能 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [UniProt] |
| 细胞定位 | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. [UniProt] |
| 产品亮点 | Related news: Fight gastric cancer by targeting Claudin 18.2 |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (4) Click the Picture to Zoom In
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ARG67014 anti-Claudin 18.2 antibody [SQab22278] IHC-P image
Immunohistochemistry: Formalin‐fixed and paraffin‐embedded Human stomach tissue stained with ARG67014 anti-Claudin 18.2 antibody [SQab22278] at 1:100 dilution.
Antigen retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0
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ARG67014 anti-Claudin 18.2 antibody [SQab22278] IHC-P image
Immunohistochemistry: Formalin‐fixed and paraffin‐embedded Human gastric cancer tissue stained with ARG67014 anti-Claudin 18.2 antibody [SQab22278] at 1:100 dilution.
Antigen retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0
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ARG67014 anti-Claudin 18.2 antibody [SQab22278] IHC-P image
Immunohistochemistry: Formalin‐fixed and paraffin‐embedded Human lung adenocarcinoma tissue stained with ARG67014 anti-Claudin 18.2 antibody [SQab22278] at 1:100 dilution.
Antigen retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0
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ARG67014 anti-Claudin 18.2 antibody [SQab22278] IHC-P image
Immunohistochemistry: Formalin‐fixed and paraffin‐embedded Human lung tissue as a negative control stained with ARG67014 anti-Claudin 18.2 antibody [SQab22278] at 1:100 dilution.
Antigen retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0
