ARG66569
anti-Claudin 7 antibody
anti-Claudin 7 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes Claudin 7 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a, kappa |
| 靶点名称 | Claudin 7 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Claudin 7. |
| 偶联标记 | Un-conjugated |
| 別名 | Claudin-7; CEPTRL2; claudin-1; CPETRL2; CLDN-7; Hs.84359 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 实际分子量 | ~ 20 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CLDN7 |
| 全名 | claudin 7 |
| 背景介绍 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] |
| 生物功能 | Plays a major role in tight junction-specific obliteration of the intercellular space. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction. [UniProt] |
| 预测分子量 | 22 kDa |
| 翻译后修饰 | Phosphorylated. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG66569 anti-Claudin 7 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human chromophobe cell renal carcinoma tissue stained with ARG66569 anti-Claudin 7 antibody at 1:200 dilution (4°C, overnight). Antigen Retrieval: Boil tissue section in Citrate buffer (pH 6.0).
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ARG66569 anti-Claudin 7 antibody WB image
Western blot: 30 µg of LnCap whole cell lysate stained with ARG66569 anti-Claudin 7 antibody at 1:1000 dilution.
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ARG66569 anti-Claudin 7 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human colon carcinoma tissue stained with ARG66569 anti-Claudin 7 antibody at 1:200 dilution (4°C, overnight). Antigen Retrieval: Boil tissue section in Citrate buffer (pH 6.0).
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ARG66569 anti-Claudin 7 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kindey tissue stained with ARG66569 anti-Claudin 7 antibody at 1:200 dilution (4°C, overnight). Antigen Retrieval: Boil tissue section in Citrate buffer (pH 6.0).
