ARG40293
anti-Collagen I propeptide (Procollagen I) antibody [PC8-7]
anti-Collagen I propeptide (Procollagen I) antibody [PC8-7] for ELISA,IHC-Formalin-fixed paraffin-embedded sections,IHC-Frozen sections,Western blot and Bovine,Dog,Horse,Human
概述
| 产品描述 | Mouse Monoclonal antibody [PC8-7] recognizes Procollagen I C-Peptide. |
|---|---|
| 反应物种 | Hu, Bov, Dog, Hrs |
| 不反应物种 | Rat, Rb |
| 应用 | ELISA, IHC-Fr, IHC-P, WB |
| 特异性 | The antibody recognizes non-denatured Human, Bovine, Dog and Horse Procollagen I. They do not react with Rat or Rabbit Procollagen I. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | PC8-7 |
| 同位型 | IgG1 |
| 靶点名称 | Pro-Collagen I |
| 抗原物种 | Human |
| 抗原 | Human Procollagen I. |
| 偶联标记 | Un-conjugated |
| 別名 | OI1; OI2; OI3; OI4; EDSC; Collagen alpha-1(I) chain; Alpha-1 type I collagen |
应用说明
| 应用建议 |
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| 应用说明 | Sandwich ELISA: ARG40293 as capture antibody; ARG40292 as detection antibody. WB: Under non-reducing and non-heating conditions. IHC: Antigen Retrieval: Proteinase K treatment. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | 10 mM PBS (pH 7.4) and 1% BSA. |
| 稳定剂 | 1% BSA |
| 浓度 | 2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | COL1A1 |
| 全名 | collagen, type I, alpha 1 |
| 背景介绍 | This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008] |
| 生物功能 | Type I collagen is a member of group I collagen (fibrillar forming collagen). [UniProt] |
| 细胞定位 | Secreted, extracellular space, extracellular matrix. [UniProt] |
| 产品亮点 | Related products: Collagen I antibodies; Pro-collagen I antibody; |
| 预测分子量 | 139 kDa |
| 翻译后修饰 | Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains. O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group. [UniProt] |
