ARG55463

anti-Cyclophilin A antibody

anti-Cyclophilin A antibody for Western blot and Human,Mouse,Rat

Immune System antibody; Signaling Transduction antibody

概述

产品描述 Rabbit Polyclonal antibody recognizes Cyclophilin A
反应物种 Hu, Ms, Rat
应用 WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 Cyclophilin A
抗原物种 Human
抗原 Recombinant protein of Human PPIA
偶联标记 Un-conjugated
別名 CYPA; Cyclosporin A-binding protein; PPIase A; CYPH; Cyclophilin A; HEL-S-69p; EC 5.2.1.8; Rotamase A; Peptidyl-prolyl cis-trans isomerase A

应用说明

应用建议
应用 推荐稀释比
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 NIH/3T3 and HeLa
实际分子量 17 kDa

属性

形式 Liquid
纯化 Affinity purification with immunogen.
缓冲液 PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 25518 Rat PPIA

GeneID: 268373 Mouse PPIA

GeneID: 5478 Human PPIA

基因名称 PPIA
全名 peptidylprolyl isomerase A (cyclophilin A)
背景介绍 This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
生物功能 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [UniProt]
产品亮点 Related products:
Cyclophilin A antibodies; Anti-Rabbit IgG secondary antibodies;
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研究领域 Immune System antibody; Signaling Transduction antibody
预测分子量 18 kDa
翻译后修饰 Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.

检测图片 (1) Click the Picture to Zoom In

  • ARG55463 anti-Cyclophilin A antibody WB image

    Western blot: NIH/3T3 and HeLa cell lysates stained with ARG55463 anti-Cyclophilin A antibody.