ARG66351
anti-Cytokeratin 14 antibody [SQab18101]
anti-Cytokeratin 14 antibody [SQab18101] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab18101] recognizes Cytokeratin 14 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab18101 |
| 同位型 | IgG |
| 靶点名称 | Cytokeratin 14 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 372-472 of Human Cytokeratin 14. |
| 偶联标记 | Un-conjugated |
| 別名 | K14; CK-14; Cytokeratin-14; Keratin, type I cytoskeletal 14; EBS3; EBS4; NFJ; Keratin-14; CK14 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT for 30 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KRT14 |
| 全名 | keratin 14, type I |
| 背景介绍 | This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008] |
| 生物功能 | The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. [UniProt] |
| 产品亮点 | Related products: Anti-Rabbit IgG secondary antibodies; Related news: Cancer Pathology Markers (SQ clones) |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG66351 anti-Cytokeratin 14 antibody [SQab18101] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded esophageal cancer tissue stained with ARG66351 anti-Cytokeratin 14 antibody [SQab18101]. Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0).
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ARG66351 anti-Cytokeratin 14 antibody [SQab18101] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded esophagus tissue stained with ARG66351 anti-Cytokeratin 14 antibody [SQab18101]. Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0).
