ARG66672
anti-Cytokeratin 17 antibody [SQab19157]
anti-Cytokeratin 17 antibody [SQab19157] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab19157] recognizes Cytokeratin 17 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab19157 |
| 同位型 | IgG |
| 靶点名称 | Cytokeratin 17 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 400-500 of Human Cytokeratin 17. |
| 偶联标记 | Un-conjugated |
| 別名 | CK-17; K17; PC2; Keratin, type I cytoskeletal 17; PC; Cytokeratin-17; Keratin-17; PCHC1; 39.1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KRT17 |
| 全名 | keratin 17, type I |
| 背景介绍 | This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008] |
| 生物功能 | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG66672 anti-Cytokeratin 17 antibody [SQab19157] IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung carcinoma tissue stained with ARG66672 anti-Cytokeratin 17 antibody [SQab19157].
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ARG66672 anti-Cytokeratin 17 antibody [SQab19157] IHC-P image
Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human esophageal carcinoma tissue stained with ARG66672 anti-Cytokeratin 17 antibody [SQab19157]. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).
