ARG62462
anti-Cytokeratin 20 antibody [Ks20.8]
anti-Cytokeratin 20 antibody [Ks20.8] for Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
CK7/CK20 Carcinoma Study antibody
概述
| 产品描述 | Mouse Monoclonal antibody [Ks20.8] recognizes Cytokeratin 20 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| 特异性 | This antibody is highly specific to cytokeratin 20 and shows no cross-reaction with other intermediate filament proteins. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | Ks20.8 |
| 同位型 | IgG2a |
| 靶点名称 | Cytokeratin 20 |
| 抗原物种 | Human |
| 抗原 | Cytoskeletal preparation from micro-dissected villi of human duodenal mucosa. |
| 偶联标记 | Un-conjugated |
| 別名 | KRT21; CK20; K20; CD20; CK-20; Keratin-20; Cytokeratin-20; Keratin, type I cytoskeletal 20; Protein IT |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS (pH 7.3), Van Gogh Yellow Diluent and 0.1% Sodium azide |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KRT20 |
| 全名 | keratin 20, type I |
| 背景介绍 | Cytokeratin 20 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytokeratin 20 plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine. [UniProt] |
| 细胞定位 | Cytoplasm |
| 研究领域 | CK7/CK20 Carcinoma Study antibody |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity). Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228. |
克隆号文献
Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation.
IHC / Human
Three differentiation states risk-stratify bladder cancer into distinct subtypes.
IHC-Fr / Human
Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.
IHC / Mouse
Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery.
FACS / Human
Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells.
ICC/IF / Human
Studying simple epithelial keratins in cells and tissues.
WB / Human
