ARG42335
anti-DDR1 antibody [51D6] (PE)
anti-DDR1 antibody [51D6] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [51D6] recognizes DDR1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 51D6 recognizes an extracellular epitope of CD167a, an approximately 97-101 kDa receptor tyrosine kinase expressed mainly on epithelial cells, but also on B cells and dendritic cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 51D6 |
| 同位型 | IgM |
| 靶点名称 | DDR1 |
| 抗原物种 | Human |
| 抗原 | CD167a-transfected NIH/3T3 cells. |
| 偶联标记 | PE |
| 別名 | PTK3; Discoidin receptor tyrosine kinase; PTK3A; CAK; Tyrosine-protein kinase CAK; NEP; NTRK4; Epithelial discoidin domain-containing receptor 1; HGK2; Protein-tyrosine kinase RTK-6; TRKE; EDDR1; DDR; Tyrosine kinase DDR; CD167 antigen-like family member A; MCK-10; CD antigen CD167a; Protein-tyrosine kinase 3A; TRK E; CD167; Cell adhesion kinase; RTK6; Epithelial discoidin domain receptor 1; MCK10; EC 2.7.10.1; Mammary carcinoma kinase 10 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | TBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q08345 Human Epithelial discoidin domain-containing receptor 1 |
|---|---|
| 基因名称 | DDR1 |
| 全名 | discoidin domain receptor tyrosine kinase 1 |
| 背景介绍 | Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
| 生物功能 | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. [UniProt] |
| 细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Isoform 4: Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 101 kDa |
| 翻译后修饰 | Autophosphorylated in response to fibrillar collagen binding. Glycosylation of Asn-211, but apparently not of Asn-260, Asn-371, or Asn-394, prevents autophosphorylation from occurring in the absence of collagen. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
-
ARG42335 anti-DDR1 antibody [51D6] (PE) FACS image
Flow Cytometry: MCF7 cells stained with ARG42335 anti-DDR1 antibody [51D6] (PE) (red) in comparison with FMO (fluorescence minus one) sample (black-dashed).
