ARG42453
anti-DR3 / TNFRSF25 antibody [JD3] (PE)
anti-DR3 / TNFRSF25 antibody [JD3] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [JD3] recognizes DR3 / TNFRSF25 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody JD3 recognizes an extracellular epitope of DR3 (APO-3, TNFRSF25), a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | JD3 |
| 同位型 | IgG1 |
| 靶点名称 | DR3 / TNFRSF25 |
| 抗原物种 | Human |
| 抗原 | Human DR3-Ig fusion protein. |
| 偶联标记 | PE |
| 別名 | WSL-1; Apo-3; Apoptosis-mediating receptor TRAMP; DDR3; DR3; Protein WSL; Protein WSL-1; TRAMP; Apoptosis-inducing receptor AIR; TNFRSF12; Death receptor 3; LARD; Apoptosis-mediating receptor DR3; TR3; APO-3; Lymphocyte-associated receptor of death; Tumor necrosis factor receptor superfamily member 25; WSL-LR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q93038 Human Tumor necrosis factor receptor superfamily member 25 |
|---|---|
| 基因名称 | TNFRSF25 |
| 全名 | tumor necrosis factor receptor superfamily, member 25 |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. [UniProt] |
| 细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 9: Cell membrane; Single-pass type I membrane protein. Isoform 11: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Isoform 7: Secreted. Isoform 8: Secreted. Isoform 10: Secreted. Isoform 12: Secreted. [UniProt] |
| 预测分子量 | 45 kDa |
| 翻译后修饰 | Glycosylated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42453 anti-DR3 / TNFRSF25 antibody [JD3] (PE) FACS image
Flow Cytometry: DR3-transfected HEK293 cells (red dots) and non-transfected HEK293 cells (black dots) stained with ARG42453 anti-DR3 / TNFRSF25 antibody [JD3] (PE).
