ARG41648
anti-DSG1 / Desmoglein 1 antibody
anti-DSG1 / Desmoglein 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DSG1 / Desmoglein 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DSG1 / Desmoglein 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human DSG1 / Desmoglein 1. |
| 偶联标记 | Un-conjugated |
| 別名 | PPKS1; Desmoglein-1; SPPK1; DGI; EPKHIA; CDHF4; DG1; Desmosomal glycoprotein 1; DSG; Cadherin family member 4; Pemphigus foliaceus antigen; EPKHE |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human skin | ||||||
| 实际分子量 | ~ 150 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DSG1 |
| 全名 | desmoglein 1 |
| 背景介绍 | This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015] |
| 生物功能 | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. [UniProt] |
| 预测分子量 | 114 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG41648 anti-DSG1 / Desmoglein 1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human cervix cancer tissue stained with ARG41648 anti-DSG1 / Desmoglein 1 antibody.
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ARG41648 anti-DSG1 / Desmoglein 1 antibody WB image
Western blot: Human skin lysate stained with ARG41648 anti-DSG1 / Desmoglein 1 antibody.
