ARG57530
anti-DUSP6 antibody
anti-DUSP6 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DUSP6 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, IP, WB |
| 特异性 | This antibody detects endogenous levels of total DUSP6. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DUSP6 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human DUSP6. |
| 偶联标记 | Un-conjugated |
| 別名 | Dual specificity protein phosphatase PYST1; MKP-3; MAP kinase phosphatase 3; MKP3; EC 3.1.3.16; PYST1; Dual specificity protein phosphatase 6; Mitogen-activated protein kinase phosphatase 3; EC 3.1.3.48; HH19 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| 阳性对照 | NIH/3T3 | ||||||||||||
| 实际分子量 | ~ 38 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by affinity chromatography. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DUSP6 |
| 全名 | dual specificity phosphatase 6 |
| 背景介绍 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] |
| 生物功能 | Inactivates MAP kinases. Has a specificity for the ERK family. [UniProt] |
| 细胞定位 | Nucleus |
| 预测分子量 | 42 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG57530 anti-DUSP6 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human thyroid stained with ARG57530 anti-DUSP6 antibody.
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ARG57530 anti-DUSP6 antibody WB image
Western blot: NIH/3T3 cell lysate stained with ARG57530 anti-DUSP6 antibody.
