ARG54352
anti-DcR3 antibody
anti-DcR3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DcR3 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | This antibody recognizes human, mouse, and rat DcR3 (33kDa). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DcR3 |
| 抗原物种 | Human |
| 抗原 | Peptide corresponding to aa 31-46 of human DcR3 precursor (accession no. |
| 偶联标记 | Un-conjugated |
| 別名 | M68E; Tumor necrosis factor receptor superfamily member 6B; M68; DCR3; Decoy receptor 3; DJ583P15.1.1; Decoy receptor for Fas ligand; DcR3; TR6 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human heart, brain and kidney |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95407 Human Tumor necrosis factor receptor superfamily member 6B |
|---|---|
| 基因名称 | TNFRSF6B |
| 全名 | tumor necrosis factor receptor superfamily, member 6b, decoy |
| 背景介绍 | Several novel members in the TNF receptor family, including DR3, DR4, DR5 and DR6, function as cell death receptors. Two decoy receptors, DcR1 and DcR2, compete with DR4 and DR5 for binding of their ligand, TRAIL. Another decoy receptor, DcR3/TR6 was discovered recently. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane-associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL- and LIGHT-induced apoptosis. DcR3 transcript is expressed in some lung and colon carcinomas and in some normal tissues. |
| 生物功能 | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 33 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG54352 anti-DcR3 antibody WB image
Western Blot: H: human heart; B: brain; K: kidney stained with ARG54352 anti-DcR3 antibody.
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ARG54352 anti-DcR3 antibody IHC-P image
Immunohistochemistry: human heart tissue stained with ARG54352 anti-DcR3 antibody at 1 μg/ml dilution.
