ARG65661
anti-Dengue virus NS1 antibody [SQab1502]
anti-Dengue virus NS1 antibody [SQab1502] for ELISA,Western blot and Dengue virus
Microbiology and Infectious Disease antibody
参考文献2
概述
| 产品描述 | Mouse Monoclonal antibody [SQab1502] recognizes Dengue virus NS1 |
|---|---|
| 反应物种 | DEN |
| 应用 | ELISA, WB |
| 特异性 | This antibody recognizes DENV2 NS1 protein. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SQab1502 |
| 同位型 | IgG |
| 靶点名称 | Dengue virus NS1 |
| 抗原物种 | Virus |
| 抗原 | Recombinant hexamer Dengue virus NS1 protein from drosophila cell |
| 偶联标记 | Un-conjugated |
| 別名 | Dengue virus NS1 antibody; Dengue virus nonstructural glycoprotein NS1 antibody |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | Recommend using ARG65660 Dengue virus NS1 antibody [SQab1501] for WB, ICC/IF studies. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS (pH 7.4) and 0.01% Thimerosal. |
| 抗菌剂 | 0.01% Thimerosal |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | DENV_gp1 |
|---|---|
| 全名 | Dengue virus nonstructural protein 1 |
| 背景介绍 | Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients' blood samples (up to 50 μg/mL) or infected cell supernatants (various from ng/mL to μg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic. |
| 生物功能 | Dengue virus (DENV) non-structural protein 1 (NS1) is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome. [Uniprot] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30252 Dengue virus NS1 ELISA Antibody Duo Related products: Dengue virus antibodies; Dengue virus ELISA Kits; Dengue virus Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: New Dengue Virus NS1 antibodies and Antibody Duo Fighting fire with fire: Genetically-engineered mosquitoes as an alternative to fight diseases Tools for studying Dengue Virus Exploring Antiviral Immune Response |
| 研究领域 | Microbiology and Infectious Disease antibody |
检测图片 (1) Click the Picture to Zoom In
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ARG65661 anti-Dengue virus NS1 antibody [SQab1502] & ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) ELISA image
ELISA: 293 cells expressed dengue virus type 2 NS1 protein (major in hexamer) detected by ARG65661 anti-Dengue virus NS1 antibody [SQab1502] as capture antibody (2.5 μg/ml), and ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) (0.5 μg/ml) as detection antibody, followed by incubation with streptavidin-HRP.
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