ARG43520
anti-ERCC2 / XPD antibody
anti-ERCC2 / XPD antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ERCC2 / XPD |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ERCC2 / XPD |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human ERCC2 / XPD. |
| 偶联标记 | Un-conjugated |
| 別名 | ACTN2; Actinin Alpha 2; F-Actin Cross-Linking Protein; Alpha-Actinin-2; Alpha-Actinin Skeletal Muscle Isoform 2; Alpha-Actinin Skeletal Muscle; CMD1AA; MYOCOZ; CMH23; CMYO8; CMYP8; MPD6 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 87 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O08811 Mouse TFIIH basal transcription factor complex helicase XPD subunit Swiss-port # P18074 Human TFIIH basal transcription factor complex helicase XPD subunit |
|---|---|
| 基因名称 | ERCC2 |
| 全名 | excision repair cross-complementation group 2 |
| 背景介绍 | The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| 生物功能 | ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. [UniProt] |
| 细胞定位 | Cytoplasm; Cytoskeleton; Nucleus. [UniProt] |
| 预测分子量 | 87 kDa |
| 翻译后修饰 | Ubl conjugation. [UniProt] |
检测图片 (5) Click the Picture to Zoom In
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ARG43520 anti-ERCC2 / XPD antibody IHC-P image
Immunohistochemistry: Human bladder epithelial carcinom stained with ARG43520 anti-ERCC2 / XPD antibody at 2 μg/ml dilution.
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ARG43520 anti-ERCC2 / XPD antibody WB image
Western blot: K562 and SiHa stained with ARG43520 anti-ERCC2 / XPD antibody at 0.5 μg/ml dilution.
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ARG43520 anti-ERCC2 / XPD antibody FACS image
Flow Cytometry: THP-1 stained with ARG43520 anti-ERCC2 / XPD antibody at 1 µg/10^6 cells dilution.
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ARG43520 anti-ERCC2 / XPD antibody IHC-P image
Immunohistochemistry: Rat testis stained with ARG43520 anti-ERCC2 / XPD antibody at 2 μg/ml dilution.
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ARG43520 anti-ERCC2 / XPD antibody IHC-P image
Immunohistochemistry: Mouse testis stained with ARG43520 anti-ERCC2 / XPD antibody at 2 μg/ml dilution.
