ARG45736
anti-Epac1 antibody
anti-Epac1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Monkey
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Epac1 |
|---|---|
| 反应物种 | Hu, Ms, Mk |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Epac1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human Epac1. |
| 偶联标记 | Un-conjugated |
| 別名 | RAPGEF3; Rap Guanine Nucleotide Exchange Factor 3; CAMP-GEFI; EPAC; Exchange Protein Directly Activated By CAMP 1; Bcm910; Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CAMP; CAMP-Regulated Guanine Nucleotide Exchange Factor I; Rap Guanine Nucleotide Exchange Factor (GEF) 3; Exchange Factor Directly Activated By CAMP 1; EPAC 1; EPAC1; RAP Guanine-Nucleotide-Exchange Factor (GEF) 3; 9330170P05Rik; HSU79275; CGEF1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | 104 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95398 Human Rap guanine nucleotide exchange factor 3 Swiss-port # Q8VCC8 Mouse Rap guanine nucleotide exchange factor 3 |
|---|---|
| 基因名称 | RAPGEF3 |
| 全名 | Rap Guanine Nucleotide Exchange Factor 3 |
| 背景介绍 | Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including Rap protein signal transduction; cellular response to cAMP; and regulation of syncytium formation by plasma membrane fusion. Located in several cellular components, including filopodium; lamellipodium; and microvillus. Implicated in nicotine dependence. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Feb 2025] |
| 生物功能 | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. [UniProt] |
| 细胞定位 | Membrane. [UniProt] |
| 预测分子量 | 104 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
