ARG53014
anti-FBXW7 antibody [SP237]
anti-FBXW7 antibody [SP237] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections and Human
Cancer antibody; Cell Biology and Cellular Response antibody
概述
| 产品描述 | Rabbit Monoclonal antibody [SP237] recognizes FBXW7 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SP237 |
| 同位型 | IgG |
| 靶点名称 | FBXW7 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from the internal region of human FBXW7 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | AGO; F-box protein FBX30; hCdc4; FBW7; FBW6; F-box/WD repeat-containing protein 7; SEL-10; hAgo; FBX30; SEL10; FBXO30; F-box and WD-40 domain-containing protein 7; CDC4; FBXW6; Archipelago homolog |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Endometrial Adenocarcinoma, Lung Squamous Cell Carcinoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by protein A/G |
| 缓冲液 | PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide |
| 抗菌剂 | < 0.1% Sodium azide |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q969H0 Human F-box/WD repeat-containing protein 7 |
|---|---|
| 背景介绍 | F-box/WD repeat-containing protein 7 (Fbxw7) is part of an ubiquitin-protein ligase complex. The complex ubiquitinates and degrades several important oncogenes such as mTOR, MYC, AURKA, JUN, and NOTCH1. Fbxw7 cooperates with PTEN for tumor suppression and is widely expressed in many normal tissues. The loss of fbxw7 is associated with malignant progression in a variety of tumors, including carcinoma of colorectum, lung, stomach, bile duct, endometrium, pancreas, breast and glioblastoma. |
| 细胞定位 | Cytoplasm, Nucleus, Nucleolus |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody |
| 预测分子量 | 80 kDa |
| 翻译后修饰 | Phosphorylation at Thr-205 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (PubMed:22608923). Ubiquitinated: autoubiquitinates following phosphorylation at Thr-205 and subsequent interaction with PIN1. Ubiquitination leads to its degradation (PubMed:22608923). |
检测图片 (1) Click the Picture to Zoom In
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ARG53014 anti-FBXW7 antibody [SP237] IHC-P image
Immunohistochemistry: Human Endometrial Adenocarcinoma stained with FBXW7 antibody [SP237] (ARG53014)
