ARG11143
anti-FOX3 / NeuN antibody
anti-FOX3 / NeuN antibody for IHC-Frozen sections and Human,Mouse,Rat
概述
| 产品描述 | Chicken Polyclonal antibody recognizes FOX3 / NeuN |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-Fr |
| 宿主 | Chicken |
| 克隆 | Polyclonal |
| 同位型 | IgY |
| 靶点名称 | FOX3 / NeuN |
| 抗原物种 | Human |
| 抗原 | The N-terminal 100 amino acids of Human FOX3 / NeuN. |
| 偶联标记 | Un-conjugated |
| 別名 | RNA binding protein fox-1 homolog 3; NEUN; FOX-3; HRNBP3; Fox-1 homolog C; FOX3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS and 5 mM Sodium azide. |
| 抗菌剂 | 5 mM Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # A6NFN3 Human RNA binding protein fox-1 homolog 3 Swiss-port # Q8BIF2 Mouse RNA binding protein fox-1 homolog 3 |
|---|---|
| 基因名称 | RBFOX3 |
| 全名 | RNA binding protein, fox-1 homolog (C. elegans) 3 |
| 背景介绍 | This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017] |
| 生物功能 | Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Note=Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment. [UniProt] |
| 预测分子量 | 34 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG11143 anti-FOX3 / NeuN antibody IHC-Fr image
Immunohistochemistry: Frozen section of Rat hippocampus tissue stained with ARG11143 anti-FOX3 / NeuN antibody (red) at 1:5000 dilution, and co-stained with ARG11062 anti-AIF1 / Iba 1 antibody (green) at 1:2000 dilution. (Sample preparation: Following transcardial perfusion with 4% paraformaldehyde, rat brain was post fixed for 24 hours, cut to 35 µM, and free-floating sections were stained with the above antibodies.).
