ARG56536
anti-GPX4 antibody
anti-GPX4 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Pig
Ferroptosis/Oxytosis Study antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GPX4 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Pig |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GPX4 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around aa. 81-93 of Human GPx4. (TQLVDLHARYAEC) |
| 偶联标记 | Un-conjugated |
| 別名 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; EC 1.11.1.12; MCSP; PHGPx; GSHPx-4; Glutathione peroxidase 4; GPx-4; snPHGPx; snGPx |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GPX4 |
| 全名 | glutathione peroxidase 4 |
| 背景介绍 | This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| 生物功能 | Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). [UniProt] |
| 产品亮点 | Related products: GPX4 antibodies; GPX4 Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: Ferroptosis/Oxytosis Antibody Panel is launched Therapeutic strategies against PDAC |
| 研究领域 | Ferroptosis/Oxytosis Study antibody |
| 预测分子量 | 22 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG56536 anti-GPX4 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human testis tissue. Antigen Retrieval: Heat mediation was performed in Citrate buffer (pH 6.0). Tissue section was stained with ARG56536 anti-GPX4 antibody at 1:80 dilution.
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ARG56536 anti-GPX4 antibody WB image
Western blot: 30 µg of 1) Rat testis and 2) Mouse brain lysates stained with ARG56536 anti-GPX4 antibody.
