ARG62498
anti-GnRHR / GnRH Receptor antibody [B470]
anti-GnRHR / GnRH Receptor antibody [B470] for IHC-Frozen sections and Human
Neuroscience antibody
概述
| 产品描述 | Mouse Monoclonal antibody [B470] recognizes GnRHR / GnRH Receptor |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-Fr |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B470 |
| 同位型 | IgG1 |
| 靶点名称 | GnRHR / GnRH Receptor |
| 抗原物种 | Human |
| 抗原 | BSA-conjugated peptide corresponding to aa. 1-29 (extracellular domain) of Human GnRHR. |
| 偶联标记 | Un-conjugated |
| 別名 | GRHR; HH7; LRHR; LHRHR; Gonadotropin-releasing hormone receptor; GnRH receptor; GNRHR1; GnRH-R |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A affinity purified |
| 缓冲液 | PBS (pH 7.2), 0.1% BSA and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 0.1% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P30968 Human Gonadotropin-releasing hormone receptor |
|---|---|
| 基因名称 | GNRHR |
| 全名 | gonadotropin-releasing hormone receptor |
| 背景介绍 | This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. [UniProt] |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 38 kDa |
