ARG56020
anti-GnRHR / GnRH Receptor antibody [F1G4]
anti-GnRHR / GnRH Receptor antibody [F1G4] for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat,Monkey
参考文献1
概述
| 产品描述 | Mouse Monoclonal antibody [F1G4 ] recognizes GnRHR / GnRH Receptor |
|---|---|
| 反应物种 | Hu, Rat, Mk |
| 预测物种 | Pig, Rb |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | F1G4 |
| 同位型 | IgG1, kappa |
| 靶点名称 | GnRHR / GnRH Receptor |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 1-29 of Human GnRHR. (MANSASPEQNQHCSAINNSIPLMQGNLPY) |
| 偶联标记 | Un-conjugated |
| 別名 | GRHR; HH7; LRHR; LHRHR; Gonadotropin-releasing hormone receptor; GnRH receptor; GNRHR1; GnRH-R |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Tris with 1 mM EDTA (pH 9.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P30968 Human Gonadotropin-releasing hormone receptor Swiss-port # P30969 Rat Gonadotropin-releasing hormone receptor |
|---|---|
| 基因名称 | GNRHR |
| 全名 | gonadotropin-releasing hormone receptor |
| 背景介绍 | This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. [UniProt] |
| 细胞定位 | Cytoplasmic |
| 预测分子量 | 38 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG56020 anti-GnRHR / GnRH Receptor antibody [F1G4] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded Human ovarian carcinoma stained with ARG56020 anti-GnRHR / GnRH Receptor antibody [F1G4].
文献引用
GnRH receptor expression and endometrial cell proliferation of Macaca nemestrina after administration of GnRH agonist in controlled ovarian stimulation procedures.
IHC-P / Monkey
