ARG55689
anti-HDGF antibody
anti-HDGF antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HDGF |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HDGF |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 171-197 (C-terminus) of Human HDGF. |
| 偶联标记 | Un-conjugated |
| 別名 | HMG1L2; HMG-1L2; HDGF; High mobility group protein 1-like 2; Hepatoma-derived growth factor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HeLa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HDGF |
| 全名 | hepatoma-derived growth factor |
| 背景介绍 | HDGF is a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016] |
| 生物功能 | HDGF Isoform 1: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). Isoform 2: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). Isoform 3: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. |
| 产品亮点 | Related products: HDGF antibodies; HDGF ELISA Kits; Anti-Rabbit IgG secondary antibodies; Related news: The most sensitive human HDGF ELISA kit The role of HDGF in tumor angiogenesis |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Sumoylated with SUMO1. Sumoylation prevents binding to chromatin. |
检测图片 (3) Click the Picture to Zoom In
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ARG55689 anti-HDGF antibody ICC/IF image
Immunofluorescence: SK-BR-3 cells stained with ARG55689 anti-HDGF antibody (green). DAPI (blue) for nuclear staining.
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ARG55689 anti-HDGF antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human hepatocarcinoma tissue stained with ARG55689 anti-HDGF antibody.
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ARG55689 anti-HDGF antibody WB image
Western blot: 35 µg of HeLa cell lysate stained with ARG55689 anti-HDGF antibody.
