ARG42950
anti-HTR1A / 5HT1A Receptor antibody
anti-HTR1A / 5HT1A Receptor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HTR1A / 5HT1A Receptor |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HTR1A / 5HT1A Receptor |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 404-422 of Human HTR1A / 5HT1A Receptor. (NKDFQNAFKKIIKCKFCRQ) |
| 偶联标记 | Un-conjugated |
| 別名 | 5-hydroxytryptamine receptor 1A; 5HT1a; ADRB2RL1; 5-HT-1A; PFMCD; ADRBRL1; Serotonin receptor 1A; 5-HT1A; G-21 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 46 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HTR1A |
| 全名 | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
| 背景介绍 | This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012] |
| 生物功能 | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 46 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG42950 anti-HTR1A / 5HT1A Receptor antibody IHC-P image
Immunohistochemistry: Human endometrial adenocarcinoma stained with ARG42950 anti-HTR1A / 5HT1A Receptor antibody.
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ARG42950 anti-HTR1A / 5HT1A Receptor antibody IHC-P image
Immunohistochemistry: Rat lymphaden adenocarcinoma stained with ARG42950 anti-HTR1A / 5HT1A Receptor antibody.
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ARG42950 anti-HTR1A / 5HT1A Receptor antibody WB image
Western blot: Rat brain and U87 cell lysates stained with ARG42950 anti-HTR1A / 5HT1A Receptor antibody.
