ARG54195
anti-Helios antibody [22F6] (PE)
anti-Helios antibody [22F6] (PE) for Flow cytometry and Human,Mouse
Controls and Markers antibody; Gene Regulation antibody; Immune System antibody
概述
| 产品描述 | PE-conjugated Hamster Monoclonal antibody [22F6] recognizes Helios |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS |
| 特异性 | The armenian hamster monoclonal antibody 22F6 recognizes Helios, a transcription factor expressed in some hematopoietic stem cells, and at high levels in thymicderived regulatory T cells. |
| 宿主 | Hamster |
| 克隆 | Monoclonal |
| 克隆号 | 22F6 |
| 同位型 | IgG |
| 靶点名称 | Helios |
| 抗原 | Peptide coresponding to the amino acids 51-107 of Helios |
| 偶联标记 | PE |
| 別名 | HELIOS; ZNF1A2; Ikaros family zinc finger protein 2; ANF1A2; Zinc finger protein Helios; ZNFN1A2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IKZF2 |
| 全名 | IKAROS family zinc finger 2 (Helios) |
| 背景介绍 | Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells. |
| 生物功能 | Associates with Ikaros at centromeric heterochromatin. [UniProt] |
| 研究领域 | Controls and Markers antibody; Gene Regulation antibody; Immune System antibody |
| 预测分子量 | 60 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG54195 anti-Helios antibody [22F6] (PE) FACS image
Flow Cytometry: Fixed and permeabilized human peripheral blood lymphocytes stained with ARG54195 anti-Helios antibody [22F6] (PE).
