ARG64734
anti-IDS / Iduronate 2 Sulfatase antibody
anti-IDS / Iduronate 2 Sulfatase antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cell Biology and Cellular Response antibody; Controls and Markers antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes IDS / Iduronate 2 Sulfatase |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | This antibody is expected to recognize isoform a (NP_000193.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IDS / Iduronate 2 Sulfatase |
| 抗原物种 | Human |
| 抗原 | C-KHFRFRDLEEDP |
| 偶联标记 | Un-conjugated |
| 別名 | ID2S; Alpha-L-iduronate sulfate sulfatase; Iduronate 2-sulfatase; Idursulfase; SIDS; EC 3.1.6.13; MPS2 |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IDS |
| 全名 | iduronate 2-sulfatase |
| 背景介绍 | This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] |
| 生物功能 | Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. [UniProt] |
| 细胞定位 | Lysosome. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Controls and Markers antibody |
| 预测分子量 | 62 kDa |
| 翻译后修饰 | The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG64734 anti-IDS / Iduronate 2 Sulfatase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human placenta tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG64734 anti-IDS / Iduronate 2 Sulfatase antibody at 3.8 µg/ml dilution followed by AP-staining.
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ARG64734 anti-IDS / Iduronate 2 Sulfatase antibody WB image
Western blot: 35 µg of Human liver lysate (in RIPA buffer) stained with ARG64734 anti-IDS / Iduronate 2 Sulfatase antibody at 0.1 µg/ml dilution and incubated at RT for 1 hour.
