ARG66112
anti-IFN lambda 2 antibody
anti-IFN lambda 2 antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IFN lambda 2 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IFN lambda 2 |
| 抗原物种 | Human |
| 抗原 | E. coli derived recombinant Human IFN lambda 2. (PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV) |
| 偶联标记 | Un-conjugated |
| 別名 | Interleukin-28A; IFN-lambda-2; Interferon lambda-2; IL28A; IL-28A; Cytokine Zcyto20 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Incubate tissue section in a buffer (proteinase K) at RT for 10 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.2) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IFNL2 |
| 全名 | interferon, lambda 2 |
| 背景介绍 | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. [UniProt] |
| 预测分子量 | 22 kDa |
检测图片 (4) Click the Picture to Zoom In
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ARG66112 anti-IFN lambda 2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded sections of normal Human skin. The recommended ARG66112 anti-IFN lambda 2 antibody concentration is 1.0 µg/ml overnight at 4°C. An alkaline phosphatase-labeled polymer detection system was used with a non-alcohol soluble red chromogen. Antigen Retrieval: Incubate tissue section in a buffer (proteinase K) at RT for 10 min.
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ARG66112 anti-IFN lambda 2 antibody WB image
Western blot: 250 - 0.24 ng of Human IFN-λ2 stained with ARG66112 anti-IFN lambda 2 antibody, under non-reducing conditions.
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ARG66112 anti-IFN lambda 2 antibody standard curve image
Sandwich ELISA: ARG66112 anti-IFN lambda 2 antibody as a capture antibody at 0.5 - 2.0 µg/ml combined with ARG66113 anti-IFN lambda 2 antibody (Biotin) as a detection antibody. Results of a typical standard run with optical density reading at 405 - 650 nm.
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ARG66112 anti-IFN lambda 2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded sections of normal Human skin. The recommended ARG66112 anti-IFN lambda 2 antibody concentration is 1.0 µg/ml overnight at 4°C. An alkaline phosphatase-labeled polymer detection system was used with a non-alcohol soluble red chromogen. Antigen Retrieval: Incubate tissue section in a buffer (proteinase K) at RT for 10 min.
